Fairfax County Police said one car flipped over and several people had to be extricated from the cars by rescue crews from the accident that occurred about 6:30 p.m.
One person suffered life-threatening injuries and was taken away in the rescue helicopter, says police public information officer Shelley Broderick. At least one other was transported by ambulance, police said.
It is unknown whether the crash was related to the weather. That intersection is on the side of Wiehle where traffic flows downhill.
Wiehle was partially closed as of 7:45 p.m. for accident investigation.